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The transdermal route of drug administration is considered safer for self-administration primarily because it involves applying medication through the skin, allowing for a more controlled and gradual absorption into the bloodstream. This method minimizes the risk of immediate adverse reactions that can occur with other routes, such as intravenous or intramuscular administration.

With transdermal patches or gels, patients can easily apply the medication themselves without the need for needles or injections, helping to reduce the risk of infection and the potential for complications that may arise from improper injection techniques. Additionally, transdermal therapies often provide consistent drug levels over an extended period, which can enhance compliance and reduce the frequency of dosing required. Therefore, the relative safety, ease of use, and the reduced risk of accidents make the transdermal route the preferable option for self-administration.