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Hydrocortisone, a corticosteroid medication, is commonly used to reduce inflammation and suppress the immune response. One of the well-documented side effects of hydrocortisone therapy is weight gain. This occurs due to several factors, including increased appetite and fluid retention, both of which are common effects of corticosteroids.

Patients on hydrocortisone may also experience changes in fat distribution, leading to increased fat deposits around the abdomen and face. As the body adjusts to the medication, metabolic changes can further contribute to weight gain over time. Understanding this side effect is crucial for healthcare professionals managing patients on corticosteroids, as weight management becomes an important aspect of patient care when prescribing these medications.

The other choices do not align with the typical side effects associated with hydrocortisone. While some individuals may experience insomnia as a side effect of corticosteroids, it is not as prevalent or consistent as weight gain. Dehydration is generally not a direct side effect of hydrocortisone, and weight loss is contrary to the typical effects seen in patients taking this medication.