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The abbreviation that indicates a frequency of once daily is "OD." In medical terminology, "OD" stands for "Omni Die," which is a Latin term that translates directly to "once a day." This abbreviation is commonly used in prescriptions and medical instructions to specify that a medication or treatment should be administered one time each day.

In contrast, other abbreviations represent different dosing frequencies. For example, "BID" stands for "bis in die," meaning twice a day, while "QID" means four times a day, and "QOD" indicates every other day. Understanding these abbreviations is crucial for accurately following dosage instructions and ensuring patient safety in a medical setting.