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The intravenous route of drug delivery is distinct in that it involves the administration of medication directly into the bloodstream through a vein. This method is primarily used for rapid effects and immediate therapeutic levels of drugs, making it suitable for emergencies and certain medical conditions where quick intervention is necessary.

In contrast, routes like transdermal, inhalation, and topical delivery typically involve either a physical patch or a method to deliver medication through the skin, lungs, or to a localized area of the skin, respectively. Transdermal patches specifically are designed to release medication over time through the skin. Inhalation involves the use of devices such as nebulizers or inhalers that can deliver medication precisely to the respiratory system. Topical administration generally involves creams, ointments, or gels applied directly to the skin surface.

Thus, because intravenous delivery does not utilize any form of a physical patch, it stands apart from the other delivery methods mentioned in the options.